Canu is derived from Celera Assembler, which is no longer maintained.
Celera Assembler [Myers 2000] was designed to reconstruct mammalian chromosomal DNA sequences from the short fragments of a whole genome shotgun sequencing project. Celera Assembler was used to produce reconstructions of several large genomes, namely those of Homo sapiens [Venter 2001], Mus musculus [Mural 2002], Rattus norvegicus [unpublished data], Canis familiaris [Kirkness 2003], Drosophila melanogaster [Adams 2000], and Anopheles gambiae [Holt 2001]. Celera Assembler was shown to be very accurate when its reconstruction of the human genome was compared to independent reconstructions completed later [Istrail 2004]. It was used to reconstructing one of the first large-scale metagenomic projects [Venter 2004, Rusch 2007] and a diploid human reference [Levy 2007, Denisov 2008]. It was adapted to 454 Pyrosequencing [Miller 2008] and PacBio sequencing [Koren 2012], demonstrating finished bacterial genomes [Koren 2013] and efficient algorithms for eukaryotic assembly [Berlin 2015].
Celera Assembler was released under the GNU General Public License, version 2 as a supplement to [Istrail 2004].
Canu [Koren and Walenz 2017] was branched from Celera Assembler in 2015, and specialized for single-molecule high-noise sequences. For the most recent license information on Canu, see README.licences.
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- Miller et al. (2008) Aggressive Assembly of Pyrosequencing Reads with Mates. Bioinformatics 24(24):2818-2824
- Koren et al. (2012) Hybrid error correction and de novo assembly of single-molecule sequencing reads. Nature Biotechnology, July 2012.
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- Koren and Walenz et al. (2017) Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation. Genome Research. (2017).